PRA’s Medical Informatics (MI) group leads the industry in advancing evidence-based approaches for:
- Protocol validation
- Study feasibility
- Patient access
To enhance global accrual rates for clinical trials, PRA mines public and private databases and applies a proprietary methodology for patient and site access. This data-driven approach gives us the resources and tools to determine the number of patients being treated by population, as well as their locations, enhance the likelihood of successful accrual and minimize the cost of non-performing sites.
Evidence-Based Methodology
PRA’s MI group and therapeutic experts work in cooperation to:
- Conduct scientific and medical reviews of the site-selection process
- Work cross-functionally with global feasibility, patient access and investigator relations groups to create comprehensive clinical trial strategies
PRA uses evidence-based methodology in a stepwise approach to target the appropriate geographic areas for disease prevalence and identify investigators to satisfy study requirements. Targeted site selection uses:
- Databases for information relevant to the specific protocol (medical claims, pharmacy, diagnostic, laboratory, EMR, PubMed)
- Local treatment patterns to confirm compatibility
- Review of countries for existing approved and marketed drugs
- MI suite of searches to identify sites with the highest number of actively treated patients
